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Comparison of newborn outcomes in women with gestational diabetes mellitus treated with metformin or insulin: a randomised blinded trial.
Mesdaghinia E, Samimi M, Homaei Z, Saberi F, Moosavi SG,
Yaribakht M.
Source: Department of Obstetrics and Gynecology, Kashan University
of Medical Sciences, Kashan, Iran.
Abstract
BACKGROUND:
Few studies have been done on the use of metformin in
pregnancy and their results were not similar, therefore this research is
performed to compare neonatal outcomes of metformin and insulin in the
treatment of gestational diabetes.
METHODS:
In this prospective randomized trial, 200 pregnant women
within their 24(th) to 34(th) weeks of gestation with gestational diabetes,
single fetus pregnancy, and in need of hyperglycemia treatment were entered and
grouped as either metformin or insulin. Data related to maternal and neonatal
outcomes were recorded and analyzed.
RESULTS:
Considering data recorded of HbA1c at the beginning of
pregnancy, pregnancy induced hypertension, preeclampsia, birth weight,
dystocia, first and 5(th) min APGAR, neonatal sepsis, rout of delivery, liver
function tests of neonate, hypoglycemia, anomaly, and still birth, there were
no significant statistical differences between groups. The end pregnancy HbA1c,
maternal weight gain during pregnancy, preterm labor, neonatal jaundice,
respiratory distress and hospitalization of infants were higher in insulin
group.
CONCLUSIONS:
Considering data from this study, metformin is efficient to
control hyperglycemia in pregnancy. It is suggested performing more studies to
evaluate long term side effects of metformin in pregnancy with higher sample
size and longer follow-up of newborns.
sumber: www.ncbi.nlm.nih.gov
Tags: kumpulan jurnal kebidanan
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