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Detection of maternal deoxyribonucleic acid in peripheral blood of premature and mature newborn infants.
Lázár L, Harmath AG, Bán Z, Nagy B, Papp C, Rigó J Jr, Papp
Z.
Source: Department of Obstetrics and Gynecology, Semmelweis
University, Budapest, Hungary. lazar_levente@hotmail.com
Abstract
BACKGROUND:
Over the past decade, a lot of attention has been directed
towards the fetomaternal and maternofetal transfer of nucleated cells and
plasma DNA. In some autoimmune diseases, the fetal DNA is suspected to play an
important role in the etiology of the disease. In the same way, the presence of
maternal cells and free plasma DNA in fetal/newborn circulation gives rise to
interesting questions. The aim of our study was to detect maternal
deoxyribonucleic acid in the peripheral blood of premature and mature newborn
infants.
METHODS:
In the case of eight RhD-positive mothers-RhD-negative
newborn pairs, peripheral blood samples were collected from the newborn infants
within 35-120 min after birth. The maternal origin DNA was determined by
real-time PCR amplification of the exon 7 of the RhD-positive allele.
RESULT:
In all eight cases, the RhD exon 7 was amplified during the
PCR reaction.
CONCLUSION:
The result of our study demonstrates that maternal DNA is present
in the fetal peripheral circulation. The presence of maternally derived
cells/DNA in the blood of newborn infants might have a role in the immunization
of the newborn infants and also could be a possible explanation for
'grandmother effect' in the case of Rh-negative nulligravida patients.
sumber: www.ncbi.nlm.nih.gov
Tags: kumpulan jurnal kebidanan
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